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Increasing protein intake modulates lipid metabolism in healthy young men and women consuming a high-fat hypercaloric diet.

机译:在摄入高脂高热量饮食的健康年轻男性和女性中,蛋白质摄入的增加会调节脂质代谢。

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摘要

The objective of this study was to evaluate the effect of increasing protein intake, at the expense of carbohydrates, on intrahepatic lipids (IHLs), circulating triglycerides (TGs), and body composition in healthy humans consuming a high-fat, hypercaloric diet. A crossover randomized trial with a parallel control group was performed. After a 2-wk run-in period, participants were assigned to either the control diet [n = 10; 27.8 energy percent (en%) fat, 16.9 en% protein, 55.3 en% carbohydrates] for 4 wk or a high-fat, hypercaloric diet (n = 17; > 2 MJ/d) crossover trial with 2 periods of 2 wk, with either high-protein (HP) (37.7 en% fat, 25.7 en% protein, 36.6 en% carbohydrates) or normal-protein (NP) (39.4 en% fat, 15.4 en% protein, 45.2 en% carbohydrates) content. Measurements were performed after 2 wk of run-in (baseline), 2 wk of intervention (period 1), and 4 wk of intervention (period 2). A trend toward lower IHL and plasma TG concentrations during the HP condition compared with the NP condition was observed (IHL: 0.35 +/- 0.04% vs. 0.51 +/- 0.08%, P = 0.08; TG: 0.65 +/- 0.03 vs. 0.77 +/- 0.05 mmol/L, P = 0.07, for HP and NP, respectively). Fatmass was significantly lower (10.6 +/- 1.72 vs. 10.9 +/- 1.73 kg; P = 0.02) with the HP diet than with the NP diet, whereas fat-free mass was higher (55.7 +/- 2.79 vs. 55.2 +/- 2.80 kg; P = 0.003). This study indicated that an HP, high-fat, hypercaloric diet affects lipid metabolism. It tends to lower the IHL and circulating TG concentrations and significantly lowers fat mass and increases fat-free mass compared with an NP, high-fat, hypercaloric diet. This trail was registered at www.clinicaltrails.gov as NCT01354626.
机译:这项研究的目的是评估消耗高脂饮食的健康人增加蛋白质摄入(以碳水化合物为代价)对肝内脂质(IHL),循环甘油三酸酯(TGs)和身体成分的影响。与平行对照组进行了一项交叉随机试验。经过2周的磨合期后,参与者被分配为对照饮食[n = 10; 4周或2周2周的高脂,高热量饮食(n = 17;> 2 MJ / d)交叉试验中,脂肪含量为27.8%(能源),蛋白质为16.9%,碳水化合物为55.3%),具有高蛋白(HP)(脂肪含量37.7 en%,蛋白质25.7 en%,碳水化合物36.6 en%)或正常蛋白质(NP)(脂肪39.4 en%,蛋白质15.4 en%,碳水化合物45.2 en%)的含量。在磨合2周(基线),干预2周(周期1)和干预4 wk(周期2)之后进行测量。与NP病相比,HP病中IHL和血浆TG浓度有降低的趋势(IHL:0.35 +/- 0.04%vs.0.51 +/- 0.08%,P = 0.08; TG:0.65 +/- 0.03 vs HP和NP分别为0.77 +/- 0.05 mmol / L,P = 0.07)。 HP饮食的脂肪量显着降低(10.6 +/- 1.72 vs. 10.9 +/- 1.73 kg; P = 0.02),而NP饮食则无脂肪质量更高(55.7 +/- 2.79 vs. 55.2 + /-2.80千克; P = 0.003)。这项研究表明,HP高脂,高热量饮食会影响脂质代谢。与NP高脂,高热量饮食相比,它倾向于降低IHL和循环TG浓度,并显着降低脂肪量并增加无脂肪量。该路径已在www.clinicaltrails.gov上注册为NCT01354626。

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