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Flavonoid-Mediated Modulation of CYP3A Enzyme and P-Glycoprotein Transporter: Potential Effects on Bioavailability and Disposition of Tyrosine Kinase Inhibitors

机译：黄酮类化合物介导的CYP3A酶和P-糖蛋白转运蛋白的调节：对酪氨酸激酶抑制剂的生物利用度和布置的潜在影响

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Muzaffar Iqbal;
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1. P-Glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib, While Cytochrome P450-3A (CYP3A) Limits Its Oral Bioavailability [J] . van Hoppe Stephanie, Rood Johannes J. M., Buil Levi, Molecular pharmaceutics . 2018,第11期

机译：p-糖蛋白（MDR1 / ABCB1）限制了Bruton的酪氨酸激酶抑制剂Ibrutinib的脑渗透，而细胞色素P450-3A（CYP3A）限制了其口腔生物利用度
2. Interaction Potential of the Multitargeted Receptor Tyrosine Kinase Inhibitor Dovitinib with Drug Transporters and Drug Metabolising Enzymes Assessed in Vitro [J] . Dirk Theile, Johanna Weiss, Walter Emil Haefeli, Pharmaceutics . 2014,第4期

机译：多目标受体酪氨酸激酶抑制剂多维替尼与药物转运蛋白和药物代谢酶的相互作用的体外评估
3. The tyrosine kinase inhibitor sunitinib has unexpected and potentially important inhibitory effects on human concentrative and equilibrative nucleoside transporter proteins [J] . Wu C., Smith K. M., Yao S. Y. M., Biochemistry and Cell Biology . 2014,第6期

机译：酪氨酸激酶抑制剂舒尼替尼对人浓缩和平衡核苷转运蛋白具有意想不到且潜在重要的抑制作用
4. CNX-774, an Irreversible, Selective and Orally Bioavailable Inhibitor of Bruton's Tyrosine Kinase: In Vitro ADME, Selectivity, and Pharmacokinetic Properties [C] . Prasoon Chaturvedi, Matthew Labenski, Erica Evans, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：CNX-774，Bruton的酪氨酸激酶的不可逆转，选择性和口服生物可利用的抑制剂：体外Adme，选择性和药代动力学性能
5. Optimization of the time course of stromal modulation and minimization of drug-drug interactions in a multiple tyrosine kinase inhibitor/gemcitabine combination in pancreatic cancer [D] . Trueman, Sheryl A. 2017

机译：胰腺癌中多种酪氨酸激酶抑制剂/吉西他滨组合的基质调节时间过程的优化和药物-药物相互作用的最小化
6. Interaction Potential of the Multitargeted Receptor Tyrosine Kinase Inhibitor Dovitinib with Drug Transporters and Drug Metabolising Enzymes Assessed in Vitro [O] . Johanna Weiss, Dirk Theile, Zdenek Dvorak, 2014

机译：多目标受体酪氨酸激酶抑制剂多维替尼与药物转运蛋白和药物代谢酶的相互作用的体外评估
7. Interaction Potential of the Multitargeted Receptor Tyrosine Kinase Inhibitor Dovitinib with Drug Transporters and Drug Metabolising Enzymes Assessed in Vitro [O] . Johanna Weiss, Dirk Theile, Zdenek Dvorak, 2014

机译：多靶点受体酪氨酸激酶抑制剂Dovitinib与药物转运体和药物代谢酶体外评估的相互作用潜力

Flavonoid-Mediated Modulation of CYP3A Enzyme and P-Glycoprotein Transporter: Potential Effects on Bioavailability and Disposition of Tyrosine Kinase Inhibitors

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