combinations of bruton tyrosine kinase inhibitors and cyp3a4 inhibitors

摘要

Summary "combinations of bruton tyrosine kinase inhibitors and cyp3a4 inhibitors" the present invention provides combinations of bruton tyrosine kinase (btk) inhibitors, for example 1 - ((r) -3- (4-amino-3- (4-phenoxyphenyl) -1h-pyrazolo [3,4-d] pyrimidin-1-yl) piperidin-1-yl) prop-2-en-1-one, with cyp3a4 inhibitors. methods of treating cancer, and autoimmune disorders are also provided by administering combinations of bruton tyrosine kinase (btk) inhibitors, for example 1 - ((r) -3- (4-amino-3- (4- phenoxyphenyl) -1h-pyrazolo [3,4-d] pyrimidin-1-yl) piperidin-1-yl) prop-2-en-1-one, and cyp3a4 inhibitors.