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Impact of 8-week linoleic acid intake in soy oil on Lp-PLA2 activity in healthy adults

机译:8周亚油酸摄入在健康成年人LP-PLA2活性的8周亚油酸摄入量

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摘要

Abstract Background No intervention follow-up study has examined the association between plasma n-6 polyunsaturated fatty acids (PUFAs) and lipoprotein-associated phospholipase A2 (Lp-PLA2), which is a risk factor for cardiovascular disease (CVD). We aimed to determine whether the administration of linoleic acid (LA, 18:2n-6) in soy oil affected Lp-PLA2 activity in healthy adults. Methods Self-reported healthy participants (n = 150) were randomly assigned to three groups: a low LA group, in which 10 mL soy oil was replaced with one apple; a medium LA group, in which the typical food intake was maintained; and a high LA group, in which 1/3 cup of cooked refined rice was replaced with 9.9 g of soy oil capsules daily. Plasma fatty acids and Lp-PLA2 activity were measured along with other CVD risk factors. Results After 8 weeks of treatment, plasma LA levels decreased in the low LA group and increased in the high LA group. The high LA group showed greater increases in apolipoprotein B (apoB) and oxidized low-density lipoprotein (ox-LDL) than those in the low LA group. Plasma LA levels and Lp-PLA2 activities demonstrated greater increases in the high LA group than those in the medium and low LA groups. Changes in plasma LA positively and independently correlated with changes in Lp-PLA2 activity, which was negatively correlated with changes in collagen-epinephrine closure time (CEPI-CT). Conclusions An increase in plasma LA following intake of soy oil was independently associated with Lp-PLA2 activity, which was also related to apoB, ox-LDL and CEPI-CT. Trial registration ClinicalTrail.gov Identifier: NCT02753907 , registered 25 April 2016 (retrospectively registered).
机译:抽象背景无干预后续研究已研究等离子体的n-6多不饱和脂肪酸(PUFA)和脂蛋白相关磷脂酶A2(LP-PLA2)之间的关联,这是心血管疾病(CVD)的危险因素。我们的目的是确定是否亚油酸管理(LA,18:2N-6)豆油影响健康成人的Lp-PLA2活性。方法自我报告健康参与者(N = 150)随机分配到三个组:低LA组,其中10毫升大豆油用一个苹果取代;介质LA组,其中,所述典型的食物摄取保持;和高LA基团,其中熟精制米的1/3杯用每日9.9克豆油胶囊的替换。与其它CVD危险因素测量沿等离子体脂肪酸和LP-PLA2活性。结果治疗8周后,血浆水平LA低LA组中降低,并且高LA组中增加。高LA组显示载脂蛋白B比低LA组中更大的增加(载脂蛋白B)和氧化低密度脂蛋白(OX-LDL)。血浆水平LA和LP-PLA2活动表现出高LA组比在中,低LA组中更大的增加。在等离子体LA变化与的Lp-PLA2活性的变化,将其负在胶原肾上腺素闭合时间(CEPI-CT)的变化呈正相关和独立地相关。结论在等离子体LA的增加以下豆油的摄取是独立与LP-PLA2活性,这是也与载脂蛋白B,OX-LDL和CEPI-CT相关联。试验注册ClinicalTrail.gov标识符:NCT02753907,注册2016 4月25日(注册追溯)。

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