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Photonic-crystal membranes for optical detection of single nano-particles, designed for biosensor application

机译:专为生物传感器应用设计的用于单个纳米粒子的光学检测的光子晶体膜

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摘要

A sensor designed to detect bio-molecules is presented. The sensor exploits a planar 2D photonic crystal (PC) membrane with sub-micron thickness and through holes, to induce high optical fields that allow detection of nano-particles smaller than the diffraction limit of an optical microscope. We report on our design and fabrication of a PC membrane with a nano-particle trapped inside. We have also designed and built an imaging system where an optical microscope and a CCD camera are used to take images of the PC membrane. Results show how the trapped nano-particle appears as a bright spot in the image. In a first experimental realization of the imaging system, single particles with a radius of 75 nm can be detected.
机译:提出了一种用于检测生物分子的传感器。该传感器利用具有亚微米厚度和通孔的平面二维光子晶体(PC)膜来诱导高光场,从而允许检测小于光学显微镜衍射极限的纳米粒子。我们报告了设计和制造的PC膜的内部捕获有纳米颗粒的情况。我们还设计并建造了一个成像系统,其中使用光学显微镜和CCD相机拍摄PC膜的图像。结果表明,被捕获的纳米粒子如何在图像中显示为亮点。在成像系统的第一个实验实现中,可以检测到半径为75 nm的单个粒子。

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