Design and synthesis of 2-deoxy-2(18f)fluoro-d-glucose (18fdg)

摘要

THE FIRST SYNTHESIS of 2-deoxy-2(18F)fluoro-D-glucose (18FDG) for human studiestook place in 1976 the result of a collaboration between scientist at the National Institutes of Health, the University of Pennsylvania and Brookhaven National Laboratory which had begun three years earlier. 18FDG was developed for the specific purpose of mapping glucose metabolism in the living human brain thereby serving as a tool in the basic human neurosciences (Ido et al, 1978; Reivich et al, 1979). With 18FDG it was possible for the first time to translate the (14C)2-DG autoradiographic method (Sokoloff 1979) to the clinical arena. Around the same time that 18FDG was developed, preclinical studies suggested the utility of 18FDG for studies of myocardial metabolism (Gallagher et al, 1977) and for tumor metabolism (Som et al, 1980).