Spontaneous Cardiac Arrhythmias Induced by Bromotrifluoromethane.

摘要

Cardiac arrhythmias spontaneously appearing in monkeys exposed to CBrF3 were found to require a minimal blood pressure threshold for their production. The blood pressure threshold varied as an inverse function of the log10 of the CBrF3 concentration to which monkeys in acid-base balance were exposed. Acidosis decreased the threshold and alkalosis increased the threshold at concentrations of 10 and 20 percent CBrF3 but were without effect at 30 percent or greater concentrations. Epinephrine was found to decrease the blood pressure threshold required to trigger arrhythmias but was not necessary for their production as it is in the case of cyclopropane. The difference in individual susceptibility to the spontaneous formation of arrhythmias during exposure to CBrF3 reported by Van Stee and Back (1969) was found to be the result of differences in individual ability to maintain blood pressure during CBrF3 exposure. (Author)