Primary Dermal Irritation Potential of Guanidine Nitrate in Rabbits

摘要

The primary dermal irritation potential of guanidine nitrate was determined in male and female New Zealand White rabbits using a modified Draize method. The test compound was classified as a severe primary irritant with corrosive properties. Erythema, edema, and eschar formation (injuries in depth) were detected at 24, 48, and 72 hours after dosing. Irreversible skin damage was apparent at the time of sacrifice, 14 days after dosing. Keywords: Triple base propellants; Exposure physiology; Primary dermal irritation; Guanidine nitrate; Nitroguanidine; Munitions; Mammalian toxicology; Rabbits. (KT).