Toxicokinetics of T-2 Mycotoxin and Its Metabolites in Cynomolgus Monkeys

摘要

The objectives of this study were to evaluate T-2 and its metabolites in serum and urine and to examine the pharmacokinetic and metabolic profile of T-2 toxin in a nonhuman primate model. The disposition of T-2 mycotoxin and its metabolites was studied in cynomolgus monkeys after an intravenous bolus injection (14.55 micrograms/kg) of tritium-labeled T-2 toxin. Serum, urine, and feces were collected at selected intervals, while tissues were collected 28 days after dosing. T-2 and its metabolites were separated and identified by high-performance-liquid-chromatography (HPLC). Concentrations in serum declined biexponentially. Only small quantities (<1.0%) of the parent toxin and HT-2 were detected in urine. The residual 3H toxin in several organs after 28 days of exposure accounted for only 0.01% of that administered. Keywords: Mycotoxins; Phytotoxins; Metabolites. (kt/jes)