Efficient access to novel mono- and disubstituted pyrido[3,2-d]pyrimidines

Tikad A; Routier S; Akssira M; Leger JM; Jarry C; Guillaumet G

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Efficient access to novel mono- and disubstituted pyrido[3,2-d]pyrimidines

机译：有效获得新型单和双取代吡啶并[3,2-d]嘧啶

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New mono- and disubstituted pyrido[3,2-d]pyrimidines were synthesized starting from the corresponding 2,4-dichloro derivative through SNAr and palladium-catalyzed reactions. SNAr and palladium-catalyzed hydro-deshalogenation occurred selectively at position C-4. Further Suzuki cross-coupling led to C-2 and C-2,4 mono- and disubstituted compounds.

机译：从相应的2,4-二氯衍生物通过SNAr和钯催化的反应开始合成新的单取代和双取代的吡啶并[3,2-d]嘧啶。 SNAr和钯催化的加氢脱卤选择性地发生在位置C-4。进一步的Suzuki交叉偶联导致C-2和C-2,4单取代和双取代的化合物。

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《Synlett》 |2006年第12期|共5页
作者
Tikad A; Routier S; Akssira M; Leger JM; Jarry C; Guillaumet G;
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正文语种 eng
中图分类有机化学;
关键词
pyrimidines; palladium; Suzuki; SNAr; selectivity; CATALYZED COUPLING REACTIONS; KINASE INHIBITORS; 1ST FUNCTIONALIZATION; PROTECTING GROUP; PYRIDINE MOIETY; DERIVATIVES; FACILE; METHOXYBENZYL; METALATION; DIAZINES;

机译：嘧啶;钯;铃木;SNAr;选择性;催化偶联反应;激酶抑制剂;第一官能团;保护基;吡啶部分;衍生物;颗粒;甲氧基苯;金属化;二嗪;

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1. Efficient access to novel mono- and disubstituted pyrido[3,2-d]pyrimidines [J] . Tikad A, Routier S, Akssira M, Synlett . 2006,第12期

机译：有效获得新型单和双取代吡啶并[3,2-d]嘧啶
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5. Thieno[3,2-d]- and pyrrolo[3,2-d]pyrimidines and their C-nucleosides: Synthesis and biological evaluation [D] . Temburnikar, Kartik Waman 2012

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Efficient access to novel mono- and disubstituted pyrido[3,2-d]pyrimidines

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