Substituted pyrido 3′, 2′: 4, 5 thieno 3, 2-D pyrimidines and pyrido 3′, 2′: 4, 5 furo 3, 2-D pyrimidines used as inhibitors of the PDE-4 and/or the release of TNF-ALPHA

摘要

The invention relates to compounds of general formula (I); 1a, 1 b, 1 c and 1 d. The invention also relates to a method for the production thereof, pharmaceutical preparations containing said compounds and/or physiologically compatible salts thereof which can be produced therefrom and/or solvates thereof, and to the pharmaceutical use of said compounds, salts or solvates thereof as inhibitors of phosphodiesterase 4. The compounds comprise active ingredients for the treatment of diseases which can have a positive influence by inhibiting the activity of phosphodiesterase 4 and/or TNFα-release, for example, in lymphocytes, eosinophile and basophile granulocytes, macrophages and mastocytes.;