Synthesis of Several New S-Substituted Thiopyridines,Thieno[2,3-b]pyridine,Pyrido[3 ',2 ':4,5]thieno[3,2-d]-pyrimidine and Pyrido[3',2 ':4,5]thieno[3,2-d]-[1,2,3]triazines Containing Sulfonamido Moieties

摘要

Pyridine-2(1H)-thiones 1a,b reacted with the N-[4-(ami-nosulfonyl)phenyl]-2-chloroacetamide derivatives 2a,b to give the 2-(pyridin-2-yl)thio-N-[4-(aminosulfonyl)-phenyl]acetamide derivatives 3a-d which underwent intramolecular Thorpe-Ziegler cyclization to the corresponding 3-amino-N-[4- (aminosu(fonyl)phenyl]thieno [2,3-b]-pyridine-2-carboxamide derivatives 4a-d.Pyrido[3',2':4,5] thieno[3,2-d]-pyrimidin-3-yl-benzenesulfonamide derivatives 7a-d,9a,b,N-[4-(aminosulfonyl)phenyl]-3-{[(N,N-di-methylamino)methylene]amino}thieno[2,3-b]pyridine-2-carboxamide derivatives 8a-d and Pyrido[3',2':4,5] thie-no[3,2-d][1,2,3]triazin-3-ylbenzenesulfonamide derivatives 10a-d were prepared from 4a-d.