Anti-allergic Effect of Zizania latifolia Turcz Extracts

摘要

The anti-allergic effect of the methanol extract of Zizania latifolia Turcz was investigated. Methanol extract of Z. latifolia Trucz did not display any cytotoxicity activities in the IgE-sensitized RBL-2H3 cells. The extract was found to inhibit compound 48/80-induced degranulation and antigen-induced beta-hexosaminidase release as well as PMA plus A23187-induced TNF-alpha production in RBL-2H3 mast cells in a dose-dependent manner. Release of p-hexosaminidase, a marker for the release of histaminein mast cells, was inhibited with an IC_(50) value of 73.8 mu g/mL. These results suggest that Z. latifolia extracts may be useful for the prevention of type I allergic reaction.