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Prevalence of infection by different genotypes of human papillomavirus in women with cervical pathology

机译:宫颈病变妇女中不同基因型的人乳头瘤病毒感染的患病率

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Objective: To document the prevalence of different human papillomavirus (HPV) genotypes in our population, and the relationships between different genotypes with age and type of cervical pathology. Material and methods: Prospective, cross-sectional descriptive study. A total of 1007 patients were recruited among those seen at the cervical pathology clinic of Sant Joan de Déu University Hospital in Barcelona (Spain) between January 2003 and March 2011. The statistical analysis was done with SPSS v.19 software. Differences between groups were considered statistically significant at p < 0.05. Results: Most patients (73.2%) had HPV infection, and among these women the genotype was considered high-risk in 86.4%. The most frequent genotype was HPV 16, found in 31% of the patients. Other genotypes identified, in decreasing order of frequency (all <10%), were HPV 51, HPV 53, HPV 31, HPV 66, HPV 58, HPV 33 and HPV 18. Mean age of the patients with HPV infection was 32.3 years, versus 39.8 years in women without HPV infection (p < 0.05). The prevalence of HPV infection was significantly higher among women with grades 2 or 3 cervical intraepithelial neoplasia (CIN 2/3) (86%) or carcinoma (87%) than in women with grade 1 cervical intraepithelial neoplasia (CIN 1) (64%), HPV-associated changes (50%) or atypical cells (40%). Conclusions: In the population we studied, the proportion of women with infection by different genotypes of HPV 16 and HPV 18 was high. This finding confirms the need for further studies to compare the efficacy and protection of current vaccines against intraepithelial lesions and cervical cancer.
机译:目的:记录我国人群中不同人乳头瘤病毒(HPV)基因型的流行情况,以及不同基因型与年龄和宫颈病理类型之间的关系。材料和方法:前瞻性,横断面描述性研究。从2003年1月至2011年3月,在西班牙巴塞罗那的圣约翰德德大学医院的宫颈病理学门诊就诊的患者共1007例。采用SPSS v.19软件进行统计分析。两组之间的差异被认为具有统计学显着性,p <0.05。结果:大多数患者(73.2%)患有HPV感染,在这些女性中,基因型被认为是高风险的,占86.4%。最常见的基因型是HPV 16,在31%的患者中发现。鉴定出的其他基因型按照频率从高到低的顺序排列(均<10%),分别是HPV 51,HPV 53,HPV 31,HPV 66,HPV 58,HPV 33和HPV 18。与未感染HPV的女性为39.8岁相比(p <0.05)。在2级或3级宫颈上皮内瘤变(CIN 2/3)(86%)或癌变(87%)的女性中,HPV感染的发生率明显高于1级宫颈上皮内瘤变(CIN 1)(64%)的女性),HPV相关变化(50%)或非典型细胞(40%)。结论:在我们研究的人群中,感染了不同基因型HPV 16和HPV 18的女性比例很高。这一发现证实有必要进行进一步的研究,以比较当前疫苗针对上皮内病变和宫颈癌的功效和保护作用。

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