1107例宫颈病变患者人乳头瘤病毒感染及基因型分析

摘要

Objective:To investigate the human papillomavirus( HPV) infection in women living in Wuhu areas with cervical lesions and its genotype dis-tribution.Methods:Cytology test was performed in 21 HPV genotypes detected in the cervical mucus of 1 107 patients with cervical lesions.Results:In 1 107 cases,positive HPV was found in 230(20.78%),in which high-risk HPV infection was seen in 173(75.22%;173/230),low-risk in 40 (17.39%;40/230) and potential high-low-risk HPV in 17(7.39%;17/230).The most genotypes were detected in the total cases except for high-risk HPV 51 and HPV35 as well as low-risk HPV43.HPV16 infection was the highest(28.26%;65/230),followed by HPV58(23.04%;53/230),HPV33 (12.61%;29/230),HPV52 (11.74%;27/230) and HPV6 (9.57%;22/230) that was equal to HPV53.Highest HPV infection was found in women o-ver 60 years of age(42.86%),and lowest in those of 20 years or under(27.78%),yet no statistical significance was found within different ages(P >0.05).Conclusion:High-risk HPV infection was prevalent in women in Wuhu areas with cervical lesions ,and the infection was associated in general with genotype 16,58,33,52,6 and 53.%目的：了解芜湖市宫颈疾患妇女中人乳头瘤状病毒（ human papillomavirus ，HPV）感染情况及HPV基因型别的主要分布状况。方法：对1107例宫颈病变患者宫颈液基细胞学标本进行21种HPV基因型检测。结果：1107例标本中共检出HPV阳性230例，总感染率为20.78％（230／1107），其中高危型HPV感染者173例，占75.22％（173／230）；低危型HPV感染者40例，占17.39％（40／230）；高低危混合HPV感染者17例，占7.39％（17／230）。除未检出HPV高危型35型、51型和低危型43型，其余各型均有检出。 HPV各型别的感染率中HPV16最高为28.26％（65／230）；其他型别感染率在前五位的从高到低依次为HPV58（23.04％，53／230）、HPV33（12.61％，29／230）、HPV52（11.74％，27／230）、HPV6和53，后两型别的感染率相同均为9.57％（22／230）。在各年龄组受试者中，＞60岁妇女HPV感染率最高，为42.86％，其次为≤20岁（27.78％），各年龄组受试者之间HPV感染率差异无统计学意义（P＞0.05）。结论：芜湖市宫颈病变患者中人乳头状瘤病毒感染以高危型为主， HPV16、58、33、52、6和53型可能是该市妇女宫颈病变患者较易感染的主要型别。