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Language development of children born following intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation (AOA)

机译:胞浆内精子注射(ICSI)与辅助卵母细胞激活(AOA)结合后出生的孩子的语言发展

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Background The effect of assisted reproduction technology (ART) on language development is still unclear. Moreover, different techniques are introduced at rapid pace and are not always accompanied by extensive follow-up programmes. Aims To investigate the language development of 3-10-year-old children born following ART using intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation (AOA), which is a highly specialized technique applied in cases with a history of fertilization failure following conventional ICSI. Secondly, a comparison is made between the language development of singletons and twins. Methods & Procedures Twenty children, six boys and 14 girls, born following ICSI combined with AOA and older than 3 years were included in the study. The mean age of the children was 5;4 years (range = 3;1-10;4 years; SD = 1;8 years). Expressive and receptive language development were assessed using the Clinical Evaluation of Language Fundamentals (CELF-IV-NL) for children older than 5 years and the Reynell Developmental Language Scales (RTOS) for children younger than or equal to 5 years. Outcomes & Results The mean total score for language ability (in percentiles) was 56.8 (SD = 33.6), which corresponds to normal language skills. Significantly higher scores were found for AOA singletons compared with twins. For the general language, none of the children scored within the clinical zone for language disability corresponding with a percentile lower than 5. Conclusion & Implications This study presents the first data concerning language outcome in 3-10-year-old children born following AOA. General language scores of the AOA children in this study are located within the normal ranges. The language development of singletons was significantly better compared with twins. Although the results are reassuring for language development, in future long-term follow-up studies in this population are necessary.
机译:背景技术辅助生殖技术(ART)对语言发展的影响仍不清楚。而且,不同的技术被迅速引入,并不总是伴随着广泛的后续计划。目的探讨使用胞浆内精子注射(ICSI)结合辅助卵母细胞激活(AOA)进行ART手术后出生的3-10岁儿童的语言发展,这是一种高度专业化的技术,适用于因受精失败而受精失败的患者传统的ICSI。其次,对单身和双胞胎的语言发展进行了比较。方法与程序本研究纳入了20例ICSI联合AOA后出生的3岁以上的儿童,分别为6名男孩和14名女孩。儿童的平均年龄为5; 4岁(范围= 3; 1-10; 4岁; SD = 1; 8岁)。使用5岁以上儿童的语言基础临床评估(CELF-IV-NL)和5岁以下儿童Reynell发育语言量表(RTOS)评估表达和接受语言的发展。结果与结果语言能力的平均总分(百分位数)为56.8(SD = 33.6),与普通语言水平相当。与双胞胎相比,AOA单身人士的得分明显更高。对于普通语言,没有一个儿童在语言能力障碍的临床区域内得分低于5分。结论与意义本研究提供了有关AOA出生的3-10岁儿童的语言结局的首个数据。本研究中AOA儿童的一般语言得分位于正常范围内。单身人士的语言发展明显优于双胞胎。尽管对于语言开发而言,结果令人放心,但是在将来,对该人群的长期随访研究是必要的。

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