A Comparison of Pregnancy Rates in Female Partners of Males with Sperm Laden with Antisperm Antibodies Following Intrauterine Insemination (IUI) with Sperm Treated with Chymotrypsin Galactose vs. In Vitro Fertilization (IVF) with Intracytoplasmic Sperm Injection (ICSI)

摘要

Pregnancy rates following intrauterine insemination (IUI) of untreated sperm in which the large majority are coated with antisperm antibodies (ASA) usually result in poor pregnancy rates. This retrospective study evaluated the clinical pregnancy rate and miscarriage rate following IUI with chymotrypsin galactose treated sperm vs. IVF with ICSI. The clinical pregnancy rate per IUI cycle was 13.1% (34/258) vs. 40.7% (68/167) for IVF with ICSI (p<.01). The miscarriage rates were similar (14.8% vs. 19.1%). Thus IVF with ICSI has 3 times the chance of achieving a success compared to a cycle of IUI with chymotrypsin galactose treated sperm. Nevertheless, since IVF-ET with ICSI is very expensive some couples may choose to initially try IUI with chymotrypsin galactose treated sperm despite its lower success rate.