首页> 外文期刊>Inhalation toxicology >Effects of diesel exhaust particles on left ventricular function in isoproterenol-induced myocardial injury and healthy rats.
【24h】

Effects of diesel exhaust particles on left ventricular function in isoproterenol-induced myocardial injury and healthy rats.

机译:柴油机排气颗粒对异丙肾上腺素诱发的心肌损伤和健康大鼠左心室功能的影响。

获取原文
获取原文并翻译 | 示例
获取外文期刊封面目录资料

摘要

The associations between ambient particulate matter with an aerodiameter less than 2.5 mu m (PM(2.5)) and congestive heart failure (CHF) have been reported. However, the underlying mechanisms remain unclear. We investigated the effect of diesel exhaust particles (DEPs) on left ventricular function in isoproterenol (ISO)-induced myocardial injury and healthy rats. Male Sprague-Dawley (SD) rats were injected with ISO or normal saline. Seven days later, both groups were further assigned to receive either DEPs or normal saline by intratracheal instillation (IT). Echocardiography was used to measure fractional shortening (FS) and left ventricular end-diastolic diameter (LVDd) 24 h before and after IT in each rat. Fractional shortening (FS) was significantly decreased in SD rats treated with ISO as compared to those treated with normal saline (p < .05, t-test). When FS and LVDd before and after treatment were compared in each rat, there was no difference for normal saline treatment in healthy or ISO groups. However, there was significantly lower FS before and after DEPs exposure in both groups (p < .05, paired t-test). When using SD rats treated with normal saline as a reference group, both SD rats treated with DEPs and ISO rats treated with normal saline had lower FS (p < .05 and .0001, respectively, t-test), while ISO rats treated with DEPs had the lowest FS (p < .0001, t-test). Echocardiographic assessment revealed that left ventricular function was impaired by acute DEPs exposure, and this LV function was further compromised in rats with preexisting ISO-induced myocardial injury.
机译:据报道,空气粒径小于2.5微米(PM(2.5))的环境颗粒物与充血性心力衰竭(CHF)之间存在关联。但是,其潜在机制仍不清楚。我们调查了柴油机排气颗粒(DEPs)对异丙肾上腺素(ISO)诱发的心肌损伤和健康大鼠左心室功能的影响。给雄性Sprague-Dawley(SD)大鼠注射ISO或生理盐水。七天后,通过气管内滴注(IT)将两组进一步分配为接受DEP或生理盐水。超声心动图用于测量每只大鼠IT前后24小时的分数缩短(FS)和左心室舒张末期直径(LVDd)。与用生理盐水处理的SD大鼠相比,用ISO处理的SD大鼠的分数缩短(FS)显着降低(p <.05,t-检验)。当比较每只大鼠治疗前后的FS和LVDd时,健康或ISO组的生理盐水治疗没有差异。但是,两组DEPs暴露前后的FS均显着降低(p <.05,配对t检验)。当使用生理盐水治疗的SD大鼠作为参照组时,用DEPs治疗的SD大鼠和用生理盐水治疗的ISO大鼠的FS较低(分别为t检验p <.05和.0001,而用生理盐水治疗的ISO大鼠)。 DEP的FS最低(p <.0001,t检验)。超声心动图评估显示,急性DEPs暴露会损害左心室功能,并且在已存在ISO诱发的心肌损伤的大鼠中,该LV功能会进一步受损。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号