Synthesis and Antitubercular Activity of Some 2-(4-Substituted phenyl)-3-(4-substituted phenyl)-5-methylthiazolidin-4-ones

摘要

The compounds 2-(4-substituted phenyl)-3-(4-substituted phenyl)-5-methylthiazolidin-4-ones were synthesized by condensing 4-subsriruted anilines with 4-substituted benzaldehydes by using ethanol as solvent. The synthesized compounds were heated with 2-mercaptopropionic acid in excess of benzene. The chemical nature of synthesized compounds have been confirmed by means of IR, NMR and mass data. The synthesized compounds were screened for antitubercular activity. The compounds were subjected to in vitro screening by the tube dilution technique employing the human virulent H_(37)R_v strain of M. tuberculosis using isoniazid as a reference standard. The results revealed that the test compounds Ila, IIc, IId, IIe, exhibits remarkable antitubercular activity against H_(37)R_v strain of Mycobacterium tuberculosis. The minimum inhibitory concentration (MIC) values were found in the range of 25 to 42 μ g/mL.