1- (4- fluoro phenyl) -3 (R) - 3 (S) - hydroxy -3- (4- fluoro phenyl) - propyl) -4 (S) - (4- hydroxy phenyl) in synthesis of -2- azechijinon useful trance -2- (alkoxy carbonyl ethyl) division of - lactam

摘要

(57) Abstract The racemic trance -2- formula (i) (alkoxy carbonyl ethyl) - lactam (here, R C₁ - C₇ alkyls, is 2,2,2- torihuruoroechiru or methoxy ethoxy ethyl, and as for RL the hydrogen or protective group is) process for the hydrolysis division biology or by the enzyme is disclosed, the formula which is enriched optically with this, (Ia) or (IIa) can obtain chemical compound.