Association of an SNP marker in exon 24 of a class 3 phosphoinositide-3-kinase (PIK3C3) gene with production traits in Duroc pigs.

摘要

A C left-right-arrow T single nucleotide polymorphism (SNP) on exon 24 of the swine class 3 phosphoinositide-3-kinase (PIK3C3) gene may be a genetic marker for selecting backfat (BF) thickness and carcass fat. Associations between this PIK3C3 polymorphism and production traits were therefore investigated in 739 Duroc swine. The C allele frequency in the study population was 67.9%. The PIK3C3 polymorphism exhibited significant effects upon average daily wt. gain (ADG), BF thickness, intermuscular fat content (IMF) and the size of the loin eye meat area (EMA). C alleles increased ADG, BF and IMF, and decreased EMA. Predicted differences in traits between the homozygous swine of the C and T alleles were 40 g/day for DG, 1.2 mm for BF, 0.44% for IMF and 1.6 cm2 for EMA. Furthermore, statistical models for estimating the breeding values of each trait had lower Akaike's information criterion values when PIK3C3 genotype information was added. Results suggest that the PIK3C3 polymorphism studied (C2604T) shows potential as a genetic marker for production traits in Duroc swine.