Proprioception Mediates the Association Between Systemic Inflammation and Muscle Weakness in Patients with Knee Osteoarthritis: Results from the Amsterdam Osteoarthritis Cohort

摘要

Objectives: To determine whether systemic inflammation is associated with poor proprioception; to confirm that systemic inflammation is associated with muscle weakness; and to determine whether poor proprioception mediates the association between systemic inflammation and muscleweakness in knee osteoarthritis. Design: Cross-sectional study. Subjects: A total of 689 participants with knee osteoarthritis from the Amsterdam Osteoarthritis (AMS-OA) cohort. Methods: Systemic inflammation was assessed by erythrocytesedimentation rate, knee proprioception by determining the joint motion detection threshold, and muscle strength with an isokinetic dynamometer. Linear regression models were used to estimate direct associations between systemic inflammation, proprioception and muscle strength, and the indirectassociation (mediation) between systemic inflammation and muscle strength via proprioception adjusted for potential confounders. Results: Higher erythrocyte sedimentation rates were associated with poor proprioception (p = 0.022). Poor proprioception (p p p = 0.035). Conclusion: Results suggest that systemic inflammationis associated with poor proprioception in knee osteoarthritis. Poor proprioception may be a pathway through which systemic inflammation is associated with muscle weakness in patients with knee osteoarthritis.