首页> 外国专利> Methods to treat an allergic reaction in a mammal, skin inflammation in a mammal, arthritis selected from the group consisting of osteoarthritis, psoriatic arthritis, lupus, and spondyloarthritis, chronic obstructive pulmonary disease in a patient, chronic inflammatory bowel disease in a patient , to inhibit the infiltration of eosinophils into a patient's airways, the release of mucosa into various areas of a patient, to block the lymphocyte's ige activation, to stabilize a lymphocyte's cell membrane, and to inhibit the migration of t-cells

Methods to treat an allergic reaction in a mammal, skin inflammation in a mammal, arthritis selected from the group consisting of osteoarthritis, psoriatic arthritis, lupus, and spondyloarthritis, chronic obstructive pulmonary disease in a patient, chronic inflammatory bowel disease in a patient , to inhibit the infiltration of eosinophils into a patient's airways, the release of mucosa into various areas of a patient, to block the lymphocyte's ige activation, to stabilize a lymphocyte's cell membrane, and to inhibit the migration of t-cells

机译:治疗哺乳动物的过敏反应的方法,哺乳动物的皮肤炎症,选自骨关节炎,牛皮癣关节炎,狼疮和脊椎关节炎的关节炎,患者的慢性阻塞性肺病,患者的慢性炎症性肠病,抑制嗜酸性粒细胞浸润进入患者的气道,将粘膜释放到患者的各个部位,阻止淋巴细胞的ige活化,稳定淋巴细胞的细胞膜并抑制t细胞的迁移

摘要

"METHODS FOR TREATING AN ALLERGIC REACTION IN A MAMMALIAN, CUTANEOUS INFLAMMATION IN A MAMMALIAN, SELECTED ARTHRITIS IN THE GROUP THAT CONSISTS OF OSTEOARTHRITIS, PSORIATIC ARTHRITIS, LUPUS, AND SPONDYLARCHES IN AN EMOTIONAL STRENGTH DISEASE PATIENT, TO INHIBIT EOSINOPHIL INFILTRATION IN A PATIENT'S AIRWAYS, MUCOUS RELEASE IN A PATIENT'S AIRWAYS, TO BLOCK THE IGE ACTIVATION OF A LYMPHOCYTE, TO STABILIZE THE LAMINATION CELL OF A LYMPH CELL, A LYMPH CELL OF A LYMPH CELL, AND A LYMPH CELL. OF T-CELLS ". Methods for treating allergies, skin inflammation, arthritis, chronic obstructive pulmonary disease, and treating chronic inflammatory bowel diseases are described. Also described is a method to inhibit the infiltration of eosinophils into a patient's airways, a method to inhibit mucosal release in a patient's airways, a method to block IgE activation of a lymphocyte, a method to stabilize the membrane of lymphocyte cell, thereby further preventing its involvement in the increased inflammatory response to an IgE antigen challenge, and a method for inhibiting T-cell migration. Such methods involve administering to said patient a therapeutically effective amount of a peptide having the formula f-Met-Leu-X, wherein X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr.
机译:“治疗哺乳动物变态反应的方法,在哺乳动物中选择了由关节炎,皮肤关节炎,狼疮和椎弓毛病组成的一组关节炎症,这些病因是由于病情引起的。在患者呼吸道中发生粘液释放,以阻止淋巴细胞的IGE激活,稳定淋巴细胞,淋巴细胞的淋巴细胞和T细胞的淋巴细胞的层压细胞。描述了治疗过敏,皮肤炎症,关节炎,慢性阻塞性肺疾病和治疗慢性炎症性肠病的方法。还描述了抑制嗜酸性粒细胞渗入患者气道的方法,抑制患者气道中粘膜释放的方法,阻断淋巴细胞的IgE活化的方法,稳定淋巴细胞膜的方法,从而进一步预防它参与对IgE抗原攻击的炎症反应增加,以及抑制T细胞迁移的方法。此类方法包括向所述患者施用治疗有效量的具有式f-Met-Leu-X的肽,其中X选自Tyr,Tyr-Phe,Phe-Phe和Phe-Tyr。

著录项

  • 公开/公告号BR9816097A

    专利类型

  • 公开/公告日2002-01-22

    原文格式PDF

  • 申请/专利权人 HISTATEK LLC;

    申请/专利号BR19989816097

  • 发明设计人 JOHN C. HOUCK;JAMES CLAGETT;

    申请日1998-12-03

  • 分类号A61K38/07;A61K38/06;

  • 国家 BR

  • 入库时间 2022-08-22 00:45:58

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