Malignant conversion and peritoneal dissemination after endoscopic ultrasound‐guided ethanol ablation in intraductal papillary mucinous neoplasm of the pancreas

摘要

Abstract Background With the increasing detection of pancreatic cysts, many centers have applied endoscopic ultrasound‐guided pancreatic cyst ablation ( EUS ‐ PCA ), even in intraductal papillary mucinous neoplasms ( IPMN s) of the pancreas based on early promising outcomes. However, long‐term effects of ethanol ablation have been rarely reported, especially regarding oncologic outcomes. Methods and Results We report eight cases of malignancy conversion after EUS ‐ PCA in patients with IPMN s who had worrisome features. Moreover, two patients showed tumor spillage or peritoneal seeding (carcinomatosis) after EUS ‐ PCA . Conclusions Endoscopic ultrasound‐guided pancreatic cyst ablation must not be performed as a treatment for IPMN s, considering adverse results such as tumor spillage and the lack of oncological therapeutic effect.