Design, Synthesis, and Structural Elucidation of New Pyridine and Thienopyridine Derivatives

摘要

New series of 3-cyanopyridine scaffolds were prepared from the reaction of 3-(4-bromophenyl)-1-(3,4-dimethoxyphenyl)prop-2-en-1-one with active nitriles, including malononitrile and 2-cyanothioacetamide. The newly prepared 6-(4-bromophenyl)-4-(3,4-dimethoxyphenyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile was used as a scaffold for the preparation of new series of condensed thienopyridines by its reactions with active halo compounds, namely, ethyl chloroacetate, chloroacetonitrile, phenacyl bromide, chloroacetone, and 2-chloro-N-arylacetamide. The structures of the synthesized compounds were elucidated by the elemental analysis, spectral data and chemically by their preparations with other pathways.