ISOLATION, STRUCTURAL ELUCIDATION AND SYNTHESIS OF NOVEL ANTINEOPLASTIC SUBSTANCES DENOMINATED 'COMBRETASTATINS'

摘要

New antineoplastic substances have been isolated,structurally elucidated and synthesized having ageneral structural formula of:(I)or(II)wherein: R1 is OH or OCH3;R1 is H or OCH3; or R1R2 is -OCH2O-;R3 is H or OH;R4 is OH or OCH3.These substances have been denominated "combretas-tatin A-1, -A-2, -A-3, -B-1, -B-2, -B-3 and -B-4".Pharmaceutical preparation containing the substancesand methods of treating a host inflicted with aneoplsstic growth with the preparation is described.