Consequence of Elevated Fibroblast Growth Factor 23 Levels in Acute Kidney Injury, Renal Recovery and Overall Survival in Intensive Care Unit Patients After Major Surgery

摘要

The main goal of our study was to investigate the role of increased fibroblast growth factor 23 (FGF23) levels on renal recovery and overall survival. We conducted a prospective case-control cohort study, which included 121 adult cases who developed AKI after major surgical procedures. The subjects were followed-up until the last enrolled patient survived 180days or until the time of death. Higher FGF23 levels positively correlated with serum creatinine levels (P 0.05). Significantly higher number of patients without diuresis and with FGF23 709RU/mL survived when compared to patients without diuresis and with FGF23709RU/mL (P 0.001). FGF23 levels 709RU/mL were a good predictive tool for overall mortality in a 6-month period (P 0.05). This is the first study to analyze the impact of FGF23 values on short-term renal recovery and survival of patients with AKI after major surgery. The FGF23 increase related to AKI especially in more severe stages and in patients without diuresis is an independent risk factor for mortality.