首页> 外文期刊>Powder Technology: An International Journal on the Science and Technology of Wet and Dry Particulate Systems >The modelling of carrier-wall collision with drug particle detachment for dry powder inhaler applications
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The modelling of carrier-wall collision with drug particle detachment for dry powder inhaler applications

机译:用干粉吸入器应用对药物颗粒脱离载体壁碰撞的建模

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The paper proposes a novel particle-wall collision model for calculating temporal changes of particle velocities and forces acting on the particle during the collision between an elastic particle and a plane solid wall. The purpose is to determine the maximum inertia force acting on the particle in connection with an accurate prediction of the transition between the sliding and non-sliding periods. This method is successfully applied to the calculation of drug detachment probability via particle-wall collisions within dry powder inhalers, in which fine drug particles are usually blended with larger carrier particles as one particle cluster for better dispersion. The present novel model is firstly verified in the micro-scale simulation of a single collision between the particle cluster and the wall. The simulation results reveal that the inertia force acting on drug particles is much larger than the fluid dynamic force and dominates the drug detachment. The detachment can occur through lift-off, sliding or rolling. Nearly half of the drug particles on the carrier surface can be detached by lift-off, and most of the remaining drug particles follow up with a sliding or rolling detachment. Based on these studies, a Lagrangian particle tracking algorithm is developed and is used to predict drug detachment probability within an inhaler device through one inhalation. By tracking 1024 particle clusters moving through the inhaler (i.e. the macro-scale simulation), the influence of different flow rates (i.e. 100 l/min and 70 l/min), friction coefficients between the carrier and the wall (i.e. 0.1 and 0.2), and carrier sizes (i.e. 100 pm and 500 pm) on drug detachment are investigated. The improved understanding of particle-wall collision detachment study will be the basis for optimising inhaler design. (C) 2018 Elsevier B.V. All rights reserved.
机译:本文提出了一种新的颗粒 - 壁碰撞模型,用于计算弹性颗粒和平面实心壁之间的碰撞期间作用在颗粒上作用的颗粒速度和力的时间变化。目的是确定与滑动和非滑动周期之间的过渡的精确预测作用在粒子上的最大惯性力。该方法通过干粉吸入器内的颗粒壁碰撞成功地应用于药物脱离概率的计算,其中细药颗粒通常与较大的载体颗粒作为一个颗粒混合,以便更好地分散。首先在粒子簇和墙壁之间的单一碰撞的微级模拟中验证了本发明的小型模型。仿真结果表明,作用于药物颗粒的惯性力远大于流体动力,并占据药物脱离。分离可以通过剥离,滑动或滚动发生。载体表面上的近一半的药物颗粒可以通过剥离拆卸,并且大多数剩余的药物颗粒跟进滑动或滚动脱离。基于这些研究,开发了一种拉格朗日粒子跟踪算法,通过一次吸入来预测吸入器装置内的药物分离概率。通过跟踪1024粒子簇通过吸入器(即宏观刻度模拟),不同流速(即100L / min和70L / min)的影响,载体和墙壁之间的摩擦系数(即0.1和0.2 ),研究了对药物脱离的载体尺寸(即100pm和500 pm)。改善对粒子碰撞脱离研究的理解将是优化吸入器设计的基础。 (c)2018 Elsevier B.v.保留所有权利。

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