Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow

Bertlich Mattis; Ihler Friedrich; Weiss Bernhard G.; Freytag Saskia; Jakob Mark; Strupp Michael; Pellkofer Hannah; Canis Martin

首页> 外文期刊>Otology and neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology >Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow

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Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow

机译：Fingolimod（FTY-720）能够逆转肿瘤坏死因子诱导的耳蜗血流降低

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Hypothesis: The potential of Fingolimod (FTY-720), a sphingosine-1-phosphate analogue, to revoke the changes in cochlear blood flow induced by tumor necrosis factor (TNF) was investigated.

机译：假设：研究芬兰（Fty-720），鞘氨醇-1-磷酸酯类似物，揭示肿瘤坏死因子（TNF）诱导的耳蜗血流变化的潜力。

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《Otology and neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology》 |2017年第8期|共4页
作者
Bertlich Mattis; Ihler Friedrich; Weiss Bernhard G.; Freytag Saskia; Jakob Mark; Strupp Michael; Pellkofer Hannah; Canis Martin;
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作者单位

Univ Melbourne Dept Otorhinolaryngol Head &

Neck Surg Parkville Vic Australia;

Univ Melbourne Dept Otorhinolaryngol Head &

Neck Surg Parkville Vic Australia;

Univ Melbourne Dept Otorhinolaryngol Head &

Neck Surg Parkville Vic Australia;

Univ Melbourne Walter &

Eliza Hall Inst Populat Hlth &

Immun Div Parkville Vic Australia;

Univ Melbourne Dept Otorhinolaryngol Head &

Neck Surg Parkville Vic Australia;

Munich Univ Hosp Dept Neurol Munich Germany;

Univ Med Ctr Gottingen Dept Neurol Gottingen Germany;

Univ Melbourne Dept Otorhinolaryngol Head &

Neck Surg Parkville Vic Australia;

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原文格式 PDF
正文语种 eng
中图分类耳鼻咽喉科学;
关键词
Cochlear blood flow; Fingolimod; Microcirculation; Tumor necrosis factor;

机译：耳蜗血流;佛罗里钒;微循环;肿瘤坏死因子;

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1. Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow [J] . Bertlich Mattis, Ihler Friedrich, Weiss Bernhard G., Otology and neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology . 2017,第8期

机译：Fingolimod（FTY-720）能够逆转肿瘤坏死因子诱导的耳蜗血流降低
2. Etanercept prevents decrease of cochlear blood flow dose-dependently caused by tumor necrosis factor alpha [J] . IhlerF., SharafK., BertlichM., The Annals of otology, rhinology, and laryngology . 2013,第7期

机译：依那西普预防由肿瘤坏死因子α引起的剂量依赖性的耳蜗血流减少
3. Cochlear Pericytes Are Capable of Reversibly Decreasing Capillary Diameter In Vivo After Tumor Necrosis Factor Exposure [J] . Bertlich Mattis, Ihler Friedrich, Weiss Bernhard G., Otology and neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology . 2017,第10期

机译：耳蜗细胞在肿瘤坏死因子暴露后能够在体内可逆地降低毛细血管直径
4. Pamidronate and 1a,25-dihydroxy-vitamin-D3 Reverse Titanium Particle- and Tumor Necrosis Factor-alpha-induced Altered Functions of Bone Marrow-derived Primary Human Osteoblasts [C] . Csaba Vermes, Joshua J. Jacobs, Nadim J. Hallab, Annual meeting of the Society For Biomaterials . 2003

机译：帕米膦酸和1a，25-二羟基维生素D3反钛颗粒和肿瘤坏死因子-α诱导的骨髓来源的原代人成骨细胞功能改变。
5. Impact of Hepatitis C Virus Core Protein on the Tumor Necrosis Factor Apoptosis-inducing Ligand Pathway in Peripheral Blood Mononuclear Cells [D] . Guy, Janelle. 2018

机译：丙型肝炎病毒核心蛋白对外周血单个核细胞中肿瘤坏死因子凋亡诱导配体途径的影响
6. Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced tissue factor expression and fibrin deposition in mouse meth-A sarcoma. [O] . Y. Zhang, Y. Deng, T. Wendt, 1996

机译：带有反义组织因子的静脉内体细胞基因转移通过减少小鼠坏死因子诱导的组织因子表达和小鼠meth-A肉瘤中纤维蛋白的沉积来恢复血流。
7. Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow [O] . Mattis Bertlich, Friedrich Ihler, Bernhard G. Weiss, 2017

机译：Fingolimod（FTY-720）能够逆转肿瘤坏死因子诱导的耳蜗血流降低
8. Hantaan Virus Nucleocapsid Protein Binds to Importin alpha Proteins and Inhibits Tumor Necrosis Factor Alpha-Induced Activation of Nuclear Factor Kappa B [R] . Taylor, S. L., Frias-Staheli, N., Garcia-Sastre, A., 2008

机译：汉坦病毒核衣壳蛋白与进口蛋白α蛋白结合并抑制肿瘤坏死因子α诱导的核因子κB活化

Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow

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