Influence of Rutoside Loaded Solid Lipid Nanoparticles to Enhance Oral Bioavailability: Characterization, Pharmacokinetic, and Pharmacodynamic Studies

摘要

Incorporation of miserable soluble metabolite into the suitable colloidal carrier is a great value in the treatment of metabolic disorders. Therefore, the present study rutoside has been encapsulated with palmitic acid, characterized and evaluated their pharmacokinetics and pharmacodynamic properties in diabetic rats. Yellowish-white rutoside and solid lipid matrix formulation 5 (1:8) showed monodis- perse 85 nm spherical and rod-shaped rutoside nanoparticles (RNP) with potential encapsulation efficiency (78%), zeta potential (-36.3 mV) and stability. Increased peak of serum concentration and decreased the volume of distribution (35.6 ±3.4) observed in the kinetic profile of nanoparticles. It indicated their potential bioavailability of the intestinal system. Treatment of RNP controls the hyperglycemic condition evidenced by changes in blood glucose, body weight, tissue examination, lipid and kidney profile compared with rutoside. This study concluded nano-encapsulated rutoside act as carrier system to enhance the bioavailability to develop nano based anti-diabetic agents.