SOLID LIPID COMPOSITIONS OF LIPOPHILIC COMPOUNDS FOR ENHANCED ORAL BIOAVAILABILITY

摘要

Lipophilic substances of poor oral bioavailability are mixed with at least onesolid fat and phospholipid to obtain a dried solidcomposition suitable as an oral dosage form. The solid lipid compositions areexemplified for food additives or dietary supplements suchas Coenzyme Q10 and for pharmaceuticals such as dexanabinol. The Coenzyme Q10-dry lipid mixtures shows improved drug release invitro and enhanced oral bioavailability in vivo compared to a commercial CoQ10formulation. The dexanabinol-dry lipid mixture similarlyshows greatly enhanced oral bioavailability compared to known formulations.