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SOLID LIPID COMPOSITIONS OF LIPOPHILIC COMPOUNDS FOR ENHANCED ORAL BIOAVAILABILITY
SOLID LIPID COMPOSITIONS OF LIPOPHILIC COMPOUNDS FOR ENHANCED ORAL BIOAVAILABILITY
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机译:增强口服生物利用度的脂类化合物的固体脂质成分
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摘要
A dry solid lipidic composition comprising: a first component of a lipophilic substance selected from the group consisting of a cannabinoid, a steroid, a steroid antagonist, a non-steroidal antiinflammatory agent, an antifungal agent, an antibacterial agent, an antihypertensive agent, an anti-oxidant, an anti-epileptic agent, an antiviral agent, an anticancer agent, and an antidepressant in an amount of about 0.01 to 50% by weight of the lipidic composition to provide a therapeutic effect when administered to a mammal; a second component comprising at least one fat which is a solid at about 25!C and which is present in an amount of about 20 to 75% of the weight of the lipidic composition; and a third component of at least one phospholipid which is present in an amount of about 2 to 40% by weight of the lipidic composition, with these three components totaling 100% of the lipidic composition, wherein the second and third components increase the oral availability of the lipophilic substance when administered to the mammal. 1334 א' בתמוז התשס" ד - June 20, 2004
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