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Clinical evidence of prevention strategies for capecitabine-induced hand-foot syndrome

机译:Capecitabine诱导的手足综合征预防策略的临床综合证据

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摘要

Hand-foot syndrome (HFS) is the most common adverse effect of capecitabine-containing chemotherapy. The purpose of this study was to assess the efficacies of various prevention and treatment strategies for capecitabine-induced HFS. Searches of the PubMed and Embase databases were performed to identify relevant studies. The risk ratio (RR) with the corresponding 95% confidence interval (CI) was used as an effect measure to evaluate the efficacies of these prevention and treatment strategies. Publication bias was evaluated using Begg's and Egger's tests. Overall and subgroup analyses were conducted. All statistical analyses were conducted with Stata software version 12.0. Seventeen eligible studies were included. Our results indicated that celecoxib was significantly associated with a lower incidence of grade = 2 capecitabine-induced HFS without heterogeneity (RR = 0.43, 95% CI = 0.23-0.81, I-2 = 0.0%). However, pyridoxine and topical urea/lactic acid were not effective toward preventing capecitabine-induced grade 1, 2, 3, = 1 or = 2 HFS. Moreover, pyridoxine was not effective in treating capecitabine-induced HFS. Similar results were obtained by subgroup analysis. Our results indicate that celecoxib has potential prophylactic efficacy for capecitabine-induced HFS. However, pyridoxine and topical urea/lactic acid are not associated with a decrease in the incidence of capecitabine-induced HFS.
机译:手足综合征(HFS)是含Capecitabine含化疗的最常见的不利影响。本研究的目的是评估氯他滨诱导的HFS各种预防和治疗策略的疗效。进行了PubMed和Embase数据库的搜索以识别相关研究。使用相应的95%置信区间(CI)的风险比(RR)用作评估这些预防和治疗策略的疗效的效果措施。使用BEGG和EGGER的测试评估出版物偏见。进行总体和亚组分析。所有统计分析都与Stata软件12.0版进行。包含十七项合格的研究。我们的研究结果表明,塞克西布与较低的级别和gt的发病率显着相关; = 2个Capecitabine诱导的HFS,无异质性(RR = 0.43,95%CI = 0.23-0.81,I-2 = 0.0%)。然而,吡哆醇和局部尿素/乳酸对于预防Capecitabine诱导的1,2,3,& = 1或& = 2 HFS无效。此外,吡哆醇在治疗己二酸甲含量诱导的HFS方面无效。通过亚组分析获得了类似的结果。我们的结果表明,Celecoxib对Capecitabine诱导的HFS具有潜在的预防疗效。然而,吡哆醇和局部尿素/乳酸与Capecitabine诱导的HFS的发生率降低无关。

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