Impact of genomic alterations on lapatinib treatment outcome and cell-free genomic landscape during HER2 therapy in HER2+gastric cancer patients

Kim S. T.; Banks K. C.; Pectasides F.; Kim S. Y.; Lanman R. B.; Talasaz A.; An J.; Choi M. G.; Lee J. H.; Sohn T. S.; Bae J. M.; Kim S.; Park S. H.; Park J. O.; Park Y. S.; Lim H. Y.; Kim N. K. D.; Park W.; Lee H.; Bass A. J.; Kim K.; Kang W. K.; Lee J.

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Impact of genomic alterations on lapatinib treatment outcome and cell-free genomic landscape during HER2 therapy in HER2+gastric cancer patients

机译：基因组改变在HER2 +胃癌患者HER2治疗期间Lapatinib治疗结果和无细胞基因组景观的影响

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Background: To identify predictive markers for responders in lapatinib-treated patients and to demonstrate molecular changes during lapatinib treatment via cell-free genomics.

机译：背景：鉴定Lapatinib治疗患者的响应者的预测标志物，并通过无细胞基因组学治疗Lapatinib治疗过程中的分子变化。

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来源
《Annals of oncology: official journal of the European Society for Medical Oncology》 |2018年第4期|共12页
作者
Kim S. T.; Banks K. C.; Pectasides F.; Kim S. Y.; Lanman R. B.; Talasaz A.; An J.; Choi M. G.; Lee J. H.; Sohn T. S.; Bae J. M.; Kim S.; Park S. H.; Park J. O.; Park Y. S.; Lim H. Y.; Kim N. K. D.; Park W.; Lee H.; Bass A. J.; Kim K.; Kang W. K.; Lee J.;
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作者单位

Samsung Med Ctr Dept Med Div Hematol Oncol Seoul South Korea;

Guardant Hlth Dept Med Affairs Redwood City CA USA;

Dana Farber Canc Inst Div Mol &

Cellular Oncol Boston MA 02115 USA;

Samsung Med Ctr Dept Med Div Hematol Oncol Seoul South Korea;

Guardant Hlth Dept Med Affairs Redwood City CA USA;

Guardant Hlth Dept Med Affairs Redwood City CA USA;

Sungkyunkwan Univ Sch Med Seoul South Korea;

Sungkyunkwan Univ Sch Med Seoul South Korea;

Sungkyunkwan Univ Sch Med Seoul South Korea;

Sungkyunkwan Univ Sch Med Seoul South Korea;

Sungkyunkwan Univ Sch Med Seoul South Korea;

Sungkyunkwan Univ Sch Med Seoul South Korea;

Samsung Med Ctr Dept Med Div Hematol Oncol Seoul South Korea;

Samsung Med Ctr Dept Med Div Hematol Oncol Seoul South Korea;

Samsung Med Ctr Dept Med Div Hematol Oncol Seoul South Korea;

Samsung Med Ctr Dept Med Div Hematol Oncol Seoul South Korea;

Samsung Med Ctr Samsung Genome Inst Seoul South Korea;

Samsung Med Ctr Samsung Genome Inst Seoul South Korea;

Sungkyunkwan Univ Sch Med Seoul South Korea;

Dana Farber Canc Inst Div Mol &

Cellular Oncol Boston MA 02115 USA;

Sungkyunkwan Univ Sch Med Pathol &

Translat Genom Seoul South Korea;

Samsung Med Ctr Dept Med Div Hematol Oncol Seoul South Korea;

Samsung Med Ctr Dept Med Div Hematol Oncol Seoul South Korea;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
gastric cancer; genomics; next-generation sequencing; liquid biopsy; Guardant360; ERBB2;

机译：胃癌;基因组学;下一代测序;液体活组织检查;Puarmant360;erbb2;

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专利

1. Impact of genomic alterations on lapatinib treatment outcome and cell-free genomic landscape during HER2 therapy in HER2+gastric cancer patients [J] . Kim S. T., Banks K. C., Pectasides F., Annals of oncology: official journal of the European Society for Medical Oncology . 2018,第4期

机译：基因组改变在HER2 +胃癌患者HER2治疗期间Lapatinib治疗结果和无细胞基因组景观的影响
2. The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients [J] . Zill Oliver A., Banks Kimberly C., Fairclough Stephen R., Clinical cancer research: an official journal of the American Association for Cancer Research . 2018,第15期

机译：来自21,807例晚期癌症患者的无细胞循环肿瘤DNA中可操作基因组改变的景观
3. EGFR and HER2 genomic gain in recurrent non-small cell lung cancer after surgery: impact on outcome to treatment with gefitinib and association with EGFR and KRAS mutations in a Japanese cohort. [J] . Varella Garcia M, Mitsudomi T, Yatabe Y, Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer . 2009,第3期

机译：复发性非小细胞肺癌术后的EGFR和HER2基因组学获益：对吉非替尼治疗效果的影响以及与日本队列中的EGFR和KRAS突变相关。
4. Breast Cancer Genomics: Tackling Complexity with Functional Genomics and Patient-Derived Organoids [C] . Ron Bose International Symposium on Mathematical and Computational Oncology . 2019

机译：乳腺癌基因组学：解决功能基因组学和患者衍生类生物的复杂性
5. Sequencing-Based Computational Methods for Identifying Impactful Genomic Alterations in Cancers. [D] . Joseph, Isaac Charles. 2016

机译：基于序列的计算方法，用于识别癌症中有影响的基因组变化。
6. Impact of genomic alterations on lapatinib treatment outcome and cell-free genomic landscape during HER2 therapy in HER2+ gastric cancer patients [O] . S T Kim, K C Banks, E Pectasides, -1

机译：基因组改变对HER2 +胃癌患者HER2治疗期间拉帕替尼治疗结果和无细胞基因组格局的影响
7. Impact of genomic alterations on lapatinib treatment outcome and cell-free genomic landscape during HER2 therapy in HER2+ gastric cancer patients [O] . S.T. Kim, K.C. Banks, E. Pectasides, 2018

机译：基因组改变在HER2 +胃癌患者HER2疗法期间Lapatinib治疗结果和无细胞基因组景观的影响

Impact of genomic alterations on lapatinib treatment outcome and cell-free genomic landscape during HER2 therapy in HER2+gastric cancer patients

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