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Impact of genomic alterations on lapatinib treatment outcome and cell-free genomic landscape during HER2 therapy in HER2+ gastric cancer patients

机译：基因组改变对HER2 +胃癌患者HER2治疗期间拉帕替尼治疗结果和无细胞基因组格局的影响

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摘要

BackgroundTo identify predictive markers for responders in lapatinib-treated patients and to demonstrate molecular changes during lapatinib treatment via cell-free genomics.

机译：背景为确定拉帕替尼治疗患者的应答者预测标志物，并通过无细胞基因组学证明拉帕替尼治疗期间的分子变化。

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期刊名称 Annals of Oncology
作者
S T Kim; K C Banks; E Pectasides; S Y Kim; K Kim; R B Lanman; A Talasaz; J An; M G Choi; J H Lee; T S Sohn; J M Bae; S Kim; S H Park; J O Park; Y S Park; H Y Lim; N K D Kim; W Park; H Lee; A J Bass; K Kim; W K Kang; J Lee;
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作者单位

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年(卷),期 -1(29),4
年度 -1
页码 1037–1048
总页数 12
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
gastric cancer genomics next-generation sequencing liquid biopsy Guardant360 ERBB2;

机译：胃癌;基因组学;下一代测序;液体活检;Guardant360;ERBB2;

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专利

1. Impact of genomic alterations on lapatinib treatment outcome and cell-free genomic landscape during HER2 therapy in HER2+gastric cancer patients [J] . Kim S. T., Banks K. C., Pectasides F., Annals of oncology: official journal of the European Society for Medical Oncology . 2018,第4期

机译：基因组改变在HER2 +胃癌患者HER2治疗期间Lapatinib治疗结果和无细胞基因组景观的影响
2. The Impact of Concomitant Genomic Alterations on Treatment Outcome for Trastuzumab Therapy in HER2-Positive Gastric Cancer [J] . Ji Yun Lee, Mineui Hong, Seung Tae Kim, Scientific reports. . 2015,第期

机译：伴随基因组改变对HER2阳性胃癌曲妥珠单抗治疗治疗结果的影响
3. The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients [J] . Zill Oliver A., Banks Kimberly C., Fairclough Stephen R., Clinical cancer research: an official journal of the American Association for Cancer Research . 2018,第15期

机译：来自21,807例晚期癌症患者的无细胞循环肿瘤DNA中可操作基因组改变的景观
4. Breast Cancer Genomics: Tackling Complexity with Functional Genomics and Patient-Derived Organoids [C] . Ron Bose International Symposium on Mathematical and Computational Oncology . 2019

机译：乳腺癌基因组学：解决功能基因组学和患者衍生类生物的复杂性
5. Boron Neutron Capture Therapy for HER2+ breast cancers: A feasibility study evaluating BNCT for potential role in breast conservation therapies. [D] . Jenkins, Peter Anthony. 2012

机译：HER2 +乳腺癌的硼中子捕获疗法：评估BNCT在乳腺癌保护疗法中潜在作用的可行性研究。
6. The Impact of Concomitant Genomic Alterations on Treatment Outcome for Trastuzumab Therapy in HER2-Positive Gastric Cancer [O] . Ji Yun Lee, Mineui Hong, Seung Tae Kim, -1

机译：伴随基因组改变对HER2阳性胃癌曲妥珠单抗治疗结果的影响
7. Impact of genomic alterations on lapatinib treatment outcome and cell-free genomic landscape during HER2 therapy in HER2+ gastric cancer patients [O] . S.T. Kim, K.C. Banks, E. Pectasides, 2018

机译：基因组改变在HER2 +胃癌患者HER2疗法期间Lapatinib治疗结果和无细胞基因组景观的影响

Impact of genomic alterations on lapatinib treatment outcome and cell-free genomic landscape during HER2 therapy in HER2+ gastric cancer patients

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