The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients

Zill Oliver A.; Banks Kimberly C.; Fairclough Stephen R.; Mortimer Stefanie A.; Vowles James V.; Mokhtari Reza; Gandara David R.; Mack Philip C.; Odegaard Justin I.; Nagy Rebecca J.; Baca Arthur M.; Eltoukhy Helmy; Chudova Darya I.; Lanman Richard B.; Talasaz AmirAli

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The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients

机译：来自21,807例晚期癌症患者的无细胞循环肿瘤DNA中可操作基因组改变的景观

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Purpose: Cell-free DNA (cfDNA) sequencing provides a noninvasive method for obtaining actionable genomic information to guide personalized cancer treatment, but the presence of multiple alterations in circulation related to treatment and tumor heterogeneity complicate the interpretation of the observed variants.

机译：目的：无细胞DNA（CFDNA）测序提供了获得可操作的基因组信息的非侵入性方法，以指导个性化癌症治疗，但是与治疗和肿瘤异质性有关的多种改变的存在使观察到的变体的解释复杂化。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2018年第15期|共11页
作者
Zill Oliver A.; Banks Kimberly C.; Fairclough Stephen R.; Mortimer Stefanie A.; Vowles James V.; Mokhtari Reza; Gandara David R.; Mack Philip C.; Odegaard Justin I.; Nagy Rebecca J.; Baca Arthur M.; Eltoukhy Helmy; Chudova Darya I.; Lanman Richard B.; Talasaz AmirAli;
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Guardant Hlth Inc 505 Penobscot Dr Redwood City CA 94063 USA;

Guardant Hlth Inc 505 Penobscot Dr Redwood City CA 94063 USA;

Guardant Hlth Inc 505 Penobscot Dr Redwood City CA 94063 USA;

Guardant Hlth Inc 505 Penobscot Dr Redwood City CA 94063 USA;

Guardant Hlth Inc 505 Penobscot Dr Redwood City CA 94063 USA;

Guardant Hlth Inc 505 Penobscot Dr Redwood City CA 94063 USA;

Univ Calif Davis Ctr Comprehens Canc Sacramento CA 95817 USA;

Univ Calif Davis Ctr Comprehens Canc Sacramento CA 95817 USA;

Guardant Hlth Inc 505 Penobscot Dr Redwood City CA 94063 USA;

Guardant Hlth Inc 505 Penobscot Dr Redwood City CA 94063 USA;

Guardant Hlth Inc 505 Penobscot Dr Redwood City CA 94063 USA;

Guardant Hlth Inc 505 Penobscot Dr Redwood City CA 94063 USA;

Guardant Hlth Inc 505 Penobscot Dr Redwood City CA 94063 USA;

Guardant Hlth Inc 505 Penobscot Dr Redwood City CA 94063 USA;

Guardant Hlth Inc 505 Penobscot Dr Redwood City CA 94063 USA;

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正文语种 eng
中图分类肿瘤学;
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1. The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients [J] . Zill Oliver A., Banks Kimberly C., Fairclough Stephen R., Clinical cancer research: an official journal of the American Association for Cancer Research . 2018,第15期

机译：来自21,807例晚期癌症患者的无细胞循环肿瘤DNA中可操作基因组改变的景观
2. Bias-Corrected Targeted Next-Generation Sequencing for Rapid, Multiplexed Detection of Actionable Alterations in Cell-Free DNA from Advanced Lung Cancer Patients [J] . Paweletz Cloud P., Sacher Adrian G., Raymond Chris K., Clinical cancer research: an official journal of the American Association for Cancer Research . 2016,第4期

机译：偏置校正的靶向下一代测序，用于快速，多路检测晚期肺癌患者无细胞DNA的可操作变化
3. Genotyping of Circulating Tumor DNA Reveals the Clinically Actionable Mutation Landscape of Advanced Colorectal Cancer [J] . Cao Weiguo, Xu Yaping, Chang Lianpeng, Molecular cancer therapeutics . 2019,第6期

机译：循环肿瘤DNA的基因分型揭示了晚期结直肠癌的临床可行的突变景观
4. Single Cell Genomic Profiling of Circulating Tumor Cells (CTCs) from Metastatic Colorectal Cancer (mCRC) Identify Tumor Heterogeneity and Rare Somatic Driver Alterations [C] . Stephanie Greene, Angel Rodriguez, Jerry Lee, International Molecular Medicine Tri-Conference. . 2016

机译：转移结直肠癌（MCRC）的循环肿瘤细胞（CTC）的单细胞基因组分析识别肿瘤异质性和稀有躯体驾驶员改变
5. Investigating the Use of Circulating Tumor DNA for Cancer Surveillance and Early Detection in (Pediatric) Sarcomas and Li-Fraumeni Syndrome [D] . Paramathas, Sangeetha . 2020

机译：研究使用循环肿瘤DNA进行癌症监测和早期检测（儿科）肉瘤和Li-Fraumeni综合征
6. Genomic Profiling of Circulating Tumor DNA from Patients with Extensive-Stage Small Cell Lung Cancer Identifies Potentially Actionable Alterations [O] . Jing Yang, Xiangyun Wang, Jingli Lu, 2021

机译：广泛阶段小细胞肺癌患者循环肿瘤DNA的基因组分析标识可能可操作的改变
7. The landscape of actionable genomic alterations in cell-free circulating tumor DNA from 21,807 advanced cancer patients [O] . Oliver A. Zill, Kimberly C. Banks, Stephen R. Fairclough, 2017

机译：来自21,807例晚期癌症患者的无细胞循环肿瘤DNA中可操作基因组改变的景观

The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients

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