methods for identifying a cancer stem cell zone, an adenoma-adenocarcinoma transition zone, a colon tumor, cancer stem cells, an individual with colorectal cancer likely to respond favorably to treatment with an nf-targeted therapy -kb, an individual with genomic loss of 18q / smad4 and 10q / pten, to diagnose an individual with a high degree of colon adenoma and early adenocarcinoma, and to determine the likelihood of a colon tumor in an individual undergoing a transformation. invasive if left untreated and the likelihood that an individual with colorectal cancer (CRC) will respond favorably to treatment with targeted tgf-beta therapy, and a kit to identify an adenoma-adenocarcinoma transition region in a tumor sample from colon

摘要

Methods and kits for detecting spatial alternation of pten and, optionally, smad4, cd44, and / or tp53 expression in colon tumors are described. methods and kits are useful for identifying a cancer stem cell (csc) zone within a colon tumor, identifying an adenoma-adenocarcinoma (ad-aca) transition zone in a colorectal cancer (crc) tumor, identify a crc tumor that contains a high degree of adenoma and / or early adenocarcinoma regions, identify cscs in a crc tumor, diagnose an individual with a high degree of colon adenoma and / or early adenocarcinoma, and determine the likelihood of a colon tumor in an individual undergoing an invasive transformation if left untreated.