Synthesis, Antibacterial and Lipoxygenase Activities of N-[(Dimethyl substituted)phenyl]-N-(4-chlorophenyl)-4-chlorobenzenesulfonainides

摘要

In present research work, a new series of N-[(dimethyl subsdtuted)phenyl]-N-(4-chiorophenyl)-4-chlorobenzeiiesulfonainides (5a-f) was synthesized and also evaluated for their biological activities. The reaction of 4-chlorobenzenesulfonyl chloride (1) with dimethyl substituted aniline (2a-f) in aqueous alkaline medium yielded N-[(dimethyl substituted)phenyl]-4-chlorobenzenesulfonamides (3a-f). The target compounds 5a-f were synthesized by reacting the compounds 3a-f with electrophile, 4-chlorobenzyl chloride (4) in aprotic solvent, DMF and NaH. All the synthesized compounds were characterized by IR, ~1HNMR and EIMS. All the synthesized derivatives were screened for antibacterial potential and were also subjected for lipoxygenase enzyme inhibition activity.