In silico study on the effects of I_(kur) block kinetics on prolongation of human action potential after atrial fibrillation-induced electrical remodeling

摘要

Experimentally, I_(kur) blockade by drugs exhibits diverse voltage and time dependence (13, 14, 16, 19). Previously, we have shown that various voltage- and time-dependent blockade of the rapid-delayed rectifier potassium current (I_(kur)) differently affects APD prolongation in the atrium (22), Therefore, different kinetics of I_(kur) blockade might be responsible for their distinct effects on the atrial AP. In this study we test this hypothesis by incorporating various kinetics of voltage- and time-dependent block of I_(kur) into in silico models of the human atrial AP. This study used not only a normal atrial AP model (7, 22) but also the one that incorporated the characteristics of AF remodeling (10).