isolated nucleic acid molecule, host cell, non-human transgenic animal, isolated protein, antisense oligonucleotide, sirna molecule, isolated antibody, screening methods for test compounds capable of inhibiting, enhancing or mimicking gitrl interaction with gitr, to diagnose disease, to treat a patient at risk or diagnosed with a disease, to induce and to inhibit the proliferation of a cell population containing effector cells, to block the suppression and suppression of a cell population that includes t cells. effectors in the presence of cd4 + cd25 + regulatory t cells, and to treat a disease, pharmaceutical composition, and vaccine adjuvant

摘要

"NUCLEIC ACID MOLECULES ISOLATED, HOST CELL, NON-HUMAN TRANSGENIC ANIMAL, PROTEIN ISOLATED, ANTI-SENSE OLIGONUCLEOTIDE, ISOLATED ANTIBODY OF TIBOSTOS INTOSAR TESTOS INTOSAR TIATETES WITH GITR, TO DIAGNOSE DISEASES, TO TREAT A PATIENT AT RISK OR DIAGNOSED WITH A DISEASE, TO INDUCE AND TO INHIBIT CELLULAR POPULATION CONTAINING EFFECULAR BLOCK CELL AND BLOCK CELL IN BLOCK T EFFECTORS IN THE PRESENCE OF CD4¬ + ¬CD25¬ + ¬ REGULATORY CELLS, AND TO TREAT A DISEASE, PHARMACEUTICAL COMPOSITION, AND, VACCINE ADJUVANT ". The present invention provides novel isolated and purified polynucleotides and polypeptides related to a novel glucocorticoid-induced TNF receptor (GITR) ligand. The invention also provides antibodies to the GITR ligand (GITRL). The present invention is also directed to novel methods for diagnosing, predicting, monitoring progress, and treating disorders arising from immune system dysregulation (e.g., autoimmune disorders, inflammatory diseases and transplant rejection, and cancers and infectious diseases). using GITRL and / or GITRL modulators. The present invention is further directed to novel therapeutics and therapeutic targets and methods for screening and evaluating test compounds for the intervention (treatment) and prevention of said disorders arising from immune system dysregulation, when related to GITRL and GITR.