How do we treat: upper gastrointestinal bleeding in adults with haemophilia.

摘要

UGI bleeding in PWH is often linked to the use of traditional non-steroidal anti-inflammatory drugs (tNSAIDs), such as ibuprofen, to relieve the pain of hemophilic arthropathy [2]. In the Eyster study, the risk of UGI bleeding was significantly increased after less than 1 month of tNSAID use (OR: 3.66; 95% CI: 1.1-11.9) [2]. Corticosteroids are also associated with UGI bleeding, particularly when taken concom-itantly with NSAIDs [4]. Yet as is true for the general population, UGI bleeding in PWH is most commonly attributable to peptic ulcers [5], and historically, 30% of haemophiliacs died from such bleeds [6]. Helicobacter pylori infection, which increases the risk of peptic ulcer disease [7], is another cause of UGI haemorrhage [8].