首页> 外国专利> Processes for treating an individual to improve the functioning of the upper gastrointestinal tract including the esophagus and stomach, to treat an individual to proliferate the upper gastrointestinal tract tissue, to identify peptides usable to treat inflammatory conditions, to identify peptides, usable to prevent or improve inflammatory conditions, usable to identify peptides capable of proliferating upper gastrointestinal tract tissue, to prophylactically treat an individual, to improve the growth of upper gastrointestinal tract tissue in a mammal, and to treat an individual to improve the functioning of the gastrointestinal tract upper, kit, processes to promote the growth of upper gastrointestinal tract tissue or cells, to treat a patient to restore the upper gastrointestinal tract, to determine the activity of a hormone when used in combination with glp-2, to treat to have an individual having peptide ulcers

Processes for treating an individual to improve the functioning of the upper gastrointestinal tract including the esophagus and stomach, to treat an individual to proliferate the upper gastrointestinal tract tissue, to identify peptides usable to treat inflammatory conditions, to identify peptides, usable to prevent or improve inflammatory conditions, usable to identify peptides capable of proliferating upper gastrointestinal tract tissue, to prophylactically treat an individual, to improve the growth of upper gastrointestinal tract tissue in a mammal, and to treat an individual to improve the functioning of the gastrointestinal tract upper, kit, processes to promote the growth of upper gastrointestinal tract tissue or cells, to treat a patient to restore the upper gastrointestinal tract, to determine the activity of a hormone when used in combination with glp-2, to treat to have an individual having peptide ulcers

机译:治疗个体以改善包括食道和胃在内的上消化道的功能,治疗个体以增殖上消化道组织,鉴定可用于治疗炎症的肽,鉴定可用于预防或改善的肽的方法炎症性疾病,可用于鉴定能够增殖上消化道组织的肽,预防性治疗个体,改善哺乳动物上消化道组织的生长以及治疗个体以改善胃肠道上层的功能促进上消化道组织或细胞生长,治疗患者以恢复上消化道,确定荷尔蒙与glp-2结合使用时的活性,治疗个体患有肽性溃疡的过程

摘要

"PROCESSES TO TREAT AN INDIVIDUAL TO IMPROVE THE FUNCTIONING OF THE UPPER GASTROINTESTINAL TRACT INCLUDING THE SHAFUS AND STOMACH, TO TREAT AN INDIVIDUAL TO PROLIFY THE UPPER GASTROINTESTINAL TREATMENT, TO IDENTIFY PEPTIDATE ITEMS TO TREAT IT. OR IMPROVE INFLAMMATORY CONDITIONS, USABLE TO IDENTIFY PEPTIDE CAPABLE OF PROLIFERING TISSUE IN THE UPPER GASTROINTESTINAL TRACT, TO PROPHILATICALLY TREAT AN INDIVIDUAL, TO IMPROVE THE GROWTH OF THE GASTROINTESTING TREATMENT INTO A GASTROINTESTINAL TREATMENT TO GET A MORE TREATMENT OF TREATMENT SUPERIOR GASTROINTESTINAL, KIT, PROCESSES TO PROMOTE THE GROWTH OF TISSUE GROWTH OF THE SUPERIOR GASTROINTESTINAL TRACT OR CELLS, TO TREAT A PATIENT TO RESTORE THE SUPERIOR GASTROINTESTINAL TRACT, TO DETERMINE THE ACTIVITY OF A HORMONE WHEN USED IN COMBINATION, WITH 2 COMPINATION WITH COMBINATION TIE UP AN INDIVIDUAL HAVING PEPTIDIC ULCERS ". The invention relates to glucagon-related peptides and their use for the prevention or treatment of disorders involving the upper gastrointestinal tract including the esophagus and the stomach. In particular, it has now been shown that GLP-2 and GLP-2 peptide agonists can cause tissue proliferation in the upper gastrointestinal tract. Thus, the invention provides processes of proliferation of the upper gastrointestinal tract in an individual in need of it. In addition, the processes of the invention are usable to treat or prevent inflammatory conditions of the upper gastrointestinal tract, including inflammatory diseases, GLP-2 stimulates the growth of upper gastrointestinal tissue when administered in conjunction with other peptide hormones. The invention further provides pharmaceutical compositions of GLP-2 with at least one other peptide hormone, processes for improving the growth of upper gastrointestinal tissue and gastrointestinal disorders by increasing serum levels of GLP-2 and at least one other peptide hormone. , and a kit to carry out the processes of the invention.
机译:“治疗个体以改善包括消化道和胃气肿在内的上消化道交易的功能,以治疗个体以完成上消化道疾病的治疗,以识别肽段是否要使用,以表明其是否适用于该疾病。上消化道上段的组织增生,个体化治疗,将胃肠道的生长提高到胃肠道内的治疗,以治疗更多的上消化道肥大的胃肠道前列腺癌,胃肠道或细胞,以治疗患者以恢复胃肠道的优良,确定联合使用时的激素活性,并结合使用2结合,以单独治疗上皮性溃疡。胰高血糖素相关肽及其在预防或治疗包括食道和胃的上胃肠道疾病中的用途。特别地,现在已经表明,GLP-2和GLP-2肽激动剂可以引起上胃肠道的组织增生。因此,本发明提供了在有需要的个体中上胃肠道的增殖过程。另外,本发明的方法可用于治疗或预防上消化道的炎性疾病,包括炎性疾病。当与其他肽激素联合给药时,GLP-2刺激上消化道组织的生长。本发明进一步提供了具有至少一种其他肽激素的GLP-2的药物组合物,通过增加血清中GLP-2和至少一种其他肽激素的水平来改善上消化道组织和胃肠道疾病的生长的方法。 ,以及执行本发明方法的试剂盒。

著录项

  • 公开/公告号BR9808804A

    专利类型

  • 公开/公告日2001-09-18

    原文格式PDF

  • 申请/专利权人 ONTARIO INC.;

    申请/专利号BR19989808804

  • 发明设计人 DANIEL J. DRUCKER;

    申请日1998-05-15

  • 分类号A61K38/26;A61K38/30;A61K38/27;A61K35/38;G01N33/50;C12N5/06;C12N5/08;

  • 国家 BR

  • 入库时间 2022-08-22 01:26:08

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