Experimental evaluation of biological risks of introduction of the gene-engineering-modified microorganism(GMM)B.subtilis VKPM V-7092 into the environment

摘要

Experimental evaluation of biological risks of introducing the genetically modified microorganism(GMM)B.subtilis VKPM B-7092,the active ingredient of the probiotic VETOM 1.1,into an open system has been performed.The survival of the above GMM in bovine gastroenteric tract,its influence on microbiocenosis,the species composition of microflora of the gastroenteric tract,the possibility of transfer of the DNA fragment cloned in B.subtilis bacterium and containing the gene of human leukocytic alpha-2 interferon to the representatives of intestinal microflora with administration of the probiotic VETOM 1.1,as well as its possible transfer to other microorganism species in the environment(soil)were studied.There were no negative effects of the GMM on the animal organism and the environment,including remote consequences.