Transgenic Anopheles Stephensi coexpressing single-chain antibodies resist Plasmodium falciparum development

摘要

Malaria is a disease caused by protozoan parasites transmitted among humans by the bites of infected mosquitoes. Plasmodium falciparum causes severe malaria and is transmitted by Anopheles stephensi in urban India and the Middle East. Insecticide and parasite drag resistance continue to hinder malaria eradication efforts, and thus, innovative approaches to disease control are needed to complement traditional methods (1). The goal of our work is to develop transgenic mosquitoes engineered to express genes encoding anti-parasite effector molecules.