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Mechanism of Mucosal Permeability Enhancement of CriticalSorb® (Solutol® HS15) Investigated In Vitro in Cell Cultures

机译：在细胞培养物中体外研究CriticalSorb®（Solutol®HS15）的粘膜通透性增强机制

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摘要

PurposeCriticalSorb™, with the principal component Solutol® HS15, is a novel mucosal drug delivery system demonstrated to improve the bioavailability of selected biotherapeutics. The intention of this study is to elucidate mechanism(s) responsible for the enhancement of trans-mucosal absorption of biological drugs by Solutol® HS15.

机译：PurposeCriticalSorb™的主要成分为Solutol®HS15，是一种新型粘膜药物递送系统，已证明可改善所选生物治疗剂的生物利用度。这项研究的目的是阐明导致Solutol®HS15增强生物药物的跨粘膜吸收的机制。

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期刊名称 Springer Open Choice
作者
Saif Shubber; Driton Vllasaliu; Cyril Rauch; Faron Jordan; Lisbeth Illum; Snjezana Stolnik;
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作者单位

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年(卷),期 -1(32),-1
年度 -1
页码 516–527
总页数 12
原文格式 PDF
正文语种
中图分类外科学;
关键词
absorption enhancers calu-3 cells mucosal protein delivery solutol® HS15 surfactants;

机译：吸收促进剂;calu-3细胞;粘膜蛋白递送;solutol®HS15;表面活性剂;

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专利

1. Mechanism of Mucosal Permeability Enhancement of CriticalSorb® (Solutol® HS15) Investigated In Vitro in Cell Cultures [J] . Saif Shubber, Driton Vllasaliu, Cyril Rauch, Pharmaceutical Research . 2015,第2期

机译：在细胞培养物中体外研究CriticalSorb®（Solutol®HS15）的粘膜通透性增强机制
2. Mechanism of Mucosal Permeability Enhancement of CriticalSorb (R) (Solutol (R) HS15) Investigated In Vitro in Cell Cultures [J] . Shubber Saif, Vllasaliu Driton, Rauch Cyril, Pharmaceutical research . 2015,第2期

机译：细胞培养中体外研究的CriticalSorb（R）（Solutol（R）HS15）的粘膜渗透性增强机制
3. Solutol HS15 based binary mixed micelles with penetration enhancers for augmented corneal delivery of sertaconazole nitrate: optimization, in vitro , ex vivo and in vivo characterization [J] . Nihal Farid Younes, Sally Adel Abdel-Halim, Abdelhalim I. Elassasy Drug delivery. . 2018,第1期

机译：基于Solutol HS15的二元混合胶束和渗透促进剂，用于增强硝酸舍他康唑的角膜递送：优化，体外，离体和体内表征
4. 2D and 3D in vitro culture methods to investigate endothelial-cell enhanced tumor angiogenesis [C] . Buchanan Cara F., Szot Christopher S., Freeman Joseph W., 2011 IEEE 37th Annual Northeast Bioengineering Conference . 2011

机译：2D和3D体外培养方法研究内皮细胞增强的肿瘤血管生成
5. Using a Real-Time Cellular Biosensor to Investigate in vitro Liver Culture Models; Exploring the Effect of Primary Cultures, Cell to Cell Interaction in Co-culture, and Cell to Extracellular Matrix Interactions [D] . Ciampa, Grace. 2019

机译：使用实时细胞生物传感器来研究体外肝培养模型;探讨原发性培养物，细胞对共培养细胞相互作用的影响，以及细胞对细胞基质相互作用
6. Solutol HS15 based binary mixed micelles with penetration enhancers for augmented corneal delivery of sertaconazole nitrate: optimization in vitro ex vivo and in vivo characterization [O] . Nihal Farid Younes, Sally Adel Abdel-Halim, Abdelhalim I. Elassasy 2018

机译：基于Solutol HS15的二元混合胶束具有渗透增强剂用于增强硝酸舍他康唑的角膜递送：优化体外离体和体内表征
7. Mechanism of mucosal permeability enhancement of CriticalSorb® (Solutol® HS15) investigated In Vitro in cell cultures. [O] . Shubber Saif, Vllasaliu Driton, Rauch Cyril, 2015

机译：CriticalSorb®（Solutol®HS15）的粘膜通透性增强机制已在细胞培养物中进行了体外研究。

Mechanism of Mucosal Permeability Enhancement of CriticalSorb® (Solutol® HS15) Investigated In Vitro in Cell Cultures

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