LncRNA H19 induces immune dysregulation of BMMSCs at least partly by inhibiting IL-2 production

摘要

LncRNA H19 was upregulated during SLE. A and B H19 mRNA level in the serum (A) and BMMSCs (B) of SLE patients (n = 30) was detected by RT-qPCR. C and D Association of H19 expression in serum (C) and BMMSCs (D) with SLEDAI score. E H19 mRNA level in serum and PBMCs from SLE patients (n = 30), Sjögren's syndrome (SS) patients (n = 22), rheumatoid arthritis (RA) patients (n = 9), dermatomyositis (DM) patients (n = 9), and normal control was detected by RT-qPCR. F H19 mRNA level in BMMSCs from SS patients, SLE patients, normal controls, and umbilical cord-derived MSCs (UCMSCs) was detected by RT-qPCR. *P < 0.05