MicroRNA-663 induces immune dysregulation by inhibiting TGF-β1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus

摘要

MiR-663 expression is increased in SLE BMSCs. ( ) Screening of miRNAs in BMSCs from SLE patients and normal controls (NOR). ( ) RT-PCR validation of miRNA expressions in BMSCs from 9 SLE patients and 6 NOR. ( ) Expression of SLE-associated miRNAs in BMSCs. ( and ) Association of miR-663 expression in BMSCs ( ) and serum ( ) with the SLE disease activity index (SLEDAI) score. ( , ) MiR-663 expression in serum and peripheral blood mononuclear cells (PBMCs) from SLE patients, Sjögren's syndrome (SS) patients and NOR. For others, patients with rheumatoid arthritis (RA) and dermatomyositis (DM) were included. ( ) MiR-663 expression in BMSCs from patients with SS and umbilical cord-derived MSCs (UCMSCs). All data represent the mean±SEM. * <0.05, ** <0.01, *** <0.001.