O7.4. ASSOCIATIONS BETWEEN DOPAMINE SYNTHESIS CAPACITY GLUTAMATE AND GABA LEVELS IN ANTIPSYCHOTIC-NAïVE PATIENTS WITH FIRST EPISODE PSYCHOSIS

摘要

Disturbances in the interacting dopaminergic, glutamatergic and GABAergic systems in the cortico-striato-thalamo-cortical circuits in the brain have been implicated in the pathophysiology of psychosis. Preclinical literature suggests that these disturbances are linked to each other, whereas recent clinical data have pointed to separate subgroups of patients characterized by either glutamatergic or dopaminergic abnormalities.