Methods to treat a behavioral disorder, a human patient, prostate disease, anxiety and cognitive disorders in a human patient afflicted with a condition or willing to develop a condition distinguished at least in part by the concentration of abnormal extracellular glutamate in the brain or in other nervous tissue, behavioral disorder in human, canine, feline and equine species and a patient afflicted with or willing to develop a disease comprising abnormally high glutamate concentrations in neuronal tissue or elevated naaladase levels in prostate tissue and with multiple sclerosis and to enhance cognitive function, pharmaceutical formulation and uses of an inhibitor of peptidase activity of an acidic dipeptidase bound in n-acetylated alpha and a beta-lactam compound

摘要

"METHODS FOR TREATING A BEHAVIORAL DISTURBANCE, A HUMAN PATIENT, PROSTATE DISEASE, ANXIETY DISORDERS AND COGNITIVES IN A HUMAN PATIENT AFFECTED WITH A CONDITION OR WILLING TO DEVELOP A CONCERNED UNDERSTANDING ATTENTION IN HIS CONTENT. IN ANOTHER NERVOUS TISSUE, BEHAVIORAL DISTURBANCE IN THE HUMAN, CANINE, FELINE AND EQUINE SPECIES AND A PATIENT AFFECTED WITH OR WILLING TO DEVELOP A DISEASE UNDERSTANDING ELEVATIVELY ELEVATED TYPE OF NEUTRAL ELEPHANT TYPE OF NURSING ELEPHANT TYPE OF NEUTRAL TISSUE. ENHANCING THE COGNITIVE FUNCTION, PHARMACEUTICAL FORMULATION AND USES OF AN INHIBITOR OF THE PEPTIDASE ACTIVITY OF AN ACID DIPEPTIDASE CONNECTED IN N-ACETYLATED ALPHA AND A BETA-LACTAM COMPOUND ". Administration of 225 -lactam compounds, including inhibitors of certain bacterial peptidases, has been found to produce significant neurotropic effects in warm-blooded vertebrates evidenced, inter alia, by anxiolytic and anti-aggressive behavior and cognition is believed to enhanced is mediated by inhibition of neurogenic NAALADase and related enzyme activity. 225 lactam antibiotics and 225 -lactamase inhibitors have been found to exhibit potent NAALADase inhibition and these blood-brain barrier transport compounds are effective inhibitors of neurogenic NAALADase with significant neurotherapeutic effects. 225 -lactam compounds are useful for the treatment of numerous disease states associated with glutamate abnormalities. Therapeutic methods for the use of such compounds and their pharmaceutical formulations are described.