Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK downregulation of cyclin D1 and requires p27Kip1 or p21Cip1

摘要

BackgroundThe antihyperglycemic drug metformin may have beneficial effects on the prevention and treatment of cancer. Metformin is known to activate AMP-activated protein kinase (AMPK). It has also been shown to inhibit cyclin D1 expression and proliferation of some cultured cancer cells. However, the mechanisms of action by which metformin mediates cell cycle arrest are not completely understood.